2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-133211
    Mal-PEG6-Boc 518044-37-6
    Mal-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG6-Boc
  • HY-126948
    Aminooxy-PEG1-azide 2100306-70-3 98.0%
    Aminooxy-PEG1-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Aminooxy-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Aminooxy-PEG1-azide
  • HY-138421
    Hydroxy-PEG4-methyl acetate 77303-64-1
    Hydroxy-PEG4-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG4-methyl acetate
  • HY-126950
    Aminooxy-PEG4-azide 2100306-61-2 99.81%
    Aminooxy-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Aminooxy-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Aminooxy-PEG4-azide
  • HY-143829
    t-Boc-N-amido-PEG15-Br 3012589-40-8 98.0%
    t-Boc-N-amido-PEG15-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Boc-N-amido-PEG15-Br
  • HY-147052
    Boc-Pip-butyn 1346153-07-8
    Boc-Pip-butyn is an Alkyl/ether-based PROTAC linker. Boc-Pip-butyn is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Boc-Pip-butyn
  • HY-144008B
    C8 PEG750 Ceramide 212116-76-2 99.94%
    C8 PEG750 Ceramide is a lipid product. C8 PEG750 Ceramide synthesizes a lipid bilayer carrier for the selective delivery of various diagnostic and therapeutic agents to acidic diseased cells.
    C8 PEG750 Ceramide
  • HY-W090623
    Tos-PEG2-OH 118591-58-5
    Tos-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG2-OH
  • HY-141330
    m-PEG8-thiol 651042-83-0 99.94%
    m-PEG8-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG8-thiol
  • HY-W800668
    (S,R,S)-AHPC-PEG4-NHS ester
    (S, R, S)-AHPC-PEG4-NHS ester is a PROTAC linker that incorporatess an E3 ligase ligand with a PEG4 spacer to empower PROTAC medicine chemistry. It is is reactive with amine molecule. PEG4 arm increases the molecule's solubility.
    (S,R,S)-AHPC-PEG4-NHS ester
  • HY-W039197
    Acid-PEG4-mono-methyl ester 2028284-75-3
    Acid-PEG4-mono-methyl ester is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
    Acid-PEG4-mono-methyl ester
  • HY-140879
    Boc-N-Amido-PEG4-propargyl 1219810-90-8 99.73%
    Boc-N-Amido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-N-Amido-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Boc-N-Amido-PEG4-propargyl
  • HY-W096098
    Biotin-PEG3-CH2COOH 1189560-96-0
    Biotin-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG3-CH2COOH
  • HY-141273
    Methyltetrazine-PEG8-PFP ester 2353409-49-9 98.06%
    Methyltetrazine-PEG8-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Methyltetrazine-PEG8-PFP ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Methyltetrazine-PEG8-PFP ester
  • HY-35261
    Mal-PEG2-NH2 660843-22-1
    Mal-PEG2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG2-NH2
  • HY-140284A
    DBCO-PEG6-amine TFA 99.42%
    DBCO-PEG6-amine TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG6-amine (TFA) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG6-amine TFA
  • HY-W007341R
    Pentaethylene glycol (Standard) 4792-15-8
    Pentaethylene glycol (Standard) is the analytical standard of Pentaethylene glycol. This product is intended for research and analytical applications. Pentaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Pentaethylene glycol (Standard)
  • HY-117031
    m-PEG8-MS 1059588-19-0 99.98%
    m-PEG8-MS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG8-MS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG8-MS
  • HY-130523
    Tos-PEG5-Boc 581065-94-3
    Tos-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG5-Boc
  • HY-41922
    Propargyl-PEG2-CH2COOH 944561-46-0
    Propargyl-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG2-CH2COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-CH2COOH
PROTAC Linkers Isoform Comparison

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